Friedman M, Vidyasagar R, Joseph N. A Randomized, Prospective, Double-Blind Study on the Efficacy of Dead Sea Salt Nasal Irrigations. Laryngoscope. 116:878-882, 2006.

“The study was to compare nasal irrigation using hypertonic Dead Sea salt (DSS) solution with hypertonic saline in the treatment of chronic rhinosinusitis and improvement of quality of life (QOL).– CONCLUSIONS: We present a short-term study providing level I evidence on the superiority of DSS over saline nasal irrigation for treatment of chronic rhinosinusitis.”

Cordray S, Harjo JB, Miner L. Comparison of intranasal hypertonic dead sea saline spray and intranasal aqueous triamcinolone spray in seasonal allergic rhinitis. Ear Nose Throat J.84(7):426-30, 2005.

“Dead Sea saline solution can be an effective alternative in mild-to-moderate allergic rhinitis, particularly with respect to nasal and eye symptoms. The hypertonicity of the Dead Sea solution may have a positive effect on the physiology of the nasal mucosa by improving mucociliary clearance. In addition, the dominant cation in the Dead Sea solution–magnesium–probably exerts anti-inflammatory effects on the nasal mucosa and on the systemic immune response.”

Slapak et al. Efficacy of isotonic nasal wash (seawater) in the treatment and prevention of rhinitis in children. Arch Otolaryngol Head Neck Surg. 134(1):67-74, 2008.

“Conclusion: Children who had cold or flu performed nasal irrigation showed faster resolution of some nasal symptoms during acute illness and less frequent reappearance of rhinitis subsequently as compared to children who did not perform nasal irrigation.”

Levine HL, Cordray S, Miner LA. Use of Dead Sea salt solution for chronic rhinitis and rhinosinusitis. Operative Techniques in Otolaryngology. 17, 147-150, 2006

“Conclusions: Dead sea salt is an effective irrigation and spray in the treatment of purulent rhinosinusitis, improving quality of life and rhinosinusitis symptoms. It may have its effectiveness because of the different cation composition from normal or hypertonic saline.”

Süslü N, Bajin MD, Süslü AE, Oğretmenoğlu O. Effects of buffered 2.3%, buffered 0.9%, and non-buffered 0.9% irrigation solutions on nasal mucosa after septoplasty.
Eur Arch Otorhinolaryngol.  2008.

“A prospective randomized study was designed to compare the effect of different irrigation solutions on mucociliary clearance and nasal patency and to compare the limitations of the used solutions, such as nasal burning by a visual analog scale. On the 20th day, there was a significant difference in saccharine clearance time between the hypertonic buffered seawater group and non-buffered isotonic saline (P=0.003). Buffered hypertonic seawater improved nasal airway patency more than non-buffered”.

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