Garavello W, Romagnoli M, Sordo L, Gaini RM, Berardino CD, and Angrisano A. Hypersaline nasal irrigation in children with symptomatic seasonal allergic rhinitis: a randomized study. Pediatr Allergy Immunol. 14(2): 140-143, 2003.

“This randomized clinical trial demonstrated that daily nasal irrigation with hypertonic saline in children prevents seasonal allergic rhinitis during the pollen season. This treatment was tolerable, inexpensive and effective.”

Garavello W et al. Nasal rinsing with hypertonic solution: an adjunctive treatment for pediatric seasonal allergic rhinoconjunctivitis. Int Arch Allergy Immunol, 137(4):310-314, 2005

“Conclusions: This study supports the use of nasal rinsing with hypertonic saline in the pediatric patient with seasonal allergic rhinoconjunctivitis. This treatment proved to be tolerable, inexpensive and effective.”

Cordray S, Harjo JB, Miner L. Comparison of intranasal hypertonic dead sea saline spray and intranasal aqueous triamcinolone spray in seasonal allergic rhinitis. Ear Nose Throat J. 84(7):426-30, 2005.

“Dead Sea saline solution can be an effective alternative in mild-to-moderate allergic rhinitis, particularly with respect to nasal and eye symptoms”.

Li H, Sha Q, Zuo K, Jiang H, Cheng L, Shi J, Xu G. Nasal saline irrigation facilitates control of allergic rhinitis by topical steroid in children. ORL J Otorhinolaryngol Relat Spec. 71(1):50-55, 2009
“CONCLUSION: Nasal saline irrigation can be viewed as a good adjunctive treatment option for AR. It permitted the use of less topical steroids for controlling AR in children, which will contribute to fewer side effects and less economic burden.”

Subiza JL, Subiza, J, Barjau MC, Rodríguez R, and Gavilán MJ. Inhibition of the seasonal IgE increase to Dactylis glomerata by daily sodium chloride nasal-sinus irrigation during the grass pollen season. J Allergy Clin Immunol 104:711-2, 1999.

“Twenty-five patients (19-37 years old) with a diagnosis of grass allergy were chosen, almost all patients raised their serum levels of IgE to D glomerata. However, this increase was significantly lower in patients with nasal irrigation than in controls. –“ The removal of nasal secretions in allergic patients, containing a large array of cytokines-mediators released by the activated epithelial cells or the recruited inflammatory cells, may result in an anti-inflammatory effect”.

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