Heatley DG, McConnell KE, Kille TL, Leverson GE. Nasal irrigation for the alleviation of sinonasal symptoms, Otolaryngol Head Neck Surg. 125(1):44-48, 2001.

“CONCLUSION: Daily nasal irrigation was efficacious and resulted in improvement in the symptoms of chronic sinusitis in over 70% of subjects. Medication usage was decreased in approximately one third of participants regardless of intervention.”

Bachmann G, Hommel G, Michel O: Effect of irrigation of the nose with isotonic salt solution on adult patients with chronic paranasal sinus disease. Eur Arch Otorhinolaryngol.  257(10): 537-41, 2000.
“The randomized, controlled, double-blind clinical trial showed that endonasal irrigations with salt solutions are effective in the treatment of chronic sinusitis.”

Lavigne F, Tulic MK, Gagnon J, Hamid Q. Selective irrigation of the sinuses in the management of chronic rhinosinusitis refractory to medical therapy: a promising start. J Otolaryngol-Head and Neck Surg. 33(1):10-16, 2004

“CONCLUSION: These results suggest that sinus irrigation could provide a reasonable and effective alternative to ethmoidectomy with drainage procedures and offer promise for the treatment of patients with chronic rhinosinusitis who are resistant to medical treatment.”

Rabago D et al. Efficacy of daily saline nasal irrigation among patients with sinusitis: a randomized controlled trial. J Family Practice, 51(12): 1049-55, 2002.

The randomized controlled clinical trial demonstrated that “daily saline nasal irrigation improves sinus-related quality of life, decreases symptoms, and decreases medication use in patients with frequent sinusitis. Primary care physicians can feel comfortable recommending this therapy.”

Rabago D, et al. The efficacy of hypertonic saline nasal irrigation for chronic sinonasal symptoms. Otolaryngol Head Neck Surg. 133(1):3-8, 2005.

“CONCLUSIONS: Participants with chronic sinonasal symptoms reported improved quality of life, satisfying use of hypertonic saline nasal irrigation. SIGNIFICANCE: hypertonic saline nasal irrigation is an effective adjunctive treatment of chronic sinonasal symptoms.”

Rabago D, Barrett B, Marchand L, Maberry R, and Mundt M, Qualitative Aspects of Nasal Irrigation Use by Patients With Chronic Sinus Disease in a Multimethod Study Annals of Family Medicine 4:295-301, 2006

“CONCLUSION: Hypertonic saline nasal irrigation is a safe, well-tolerated, inexpensive, effective, long-term therapy that patients with chronic sinonasal symptoms can and will use at home with minimal training and follow-up. Success with hypertonic saline nasal irrigation will likely be improved by patient education.”

Rabago D, Guerard E, Bukstein D. Nasal irrigation for chronic sinus symptoms in patients with allergic rhinitis, asthma, and nasal polyposis.WMJ. 107(2):69-75, 2008

“Patients with frequent rhinosinusitis and daily sinus symptoms, symptoms of concomitant allergic rhinitis, asthma, or polyposis may improve with hypertonic saline nasal irrigation. The parent studies offer strong evidence that hypertonic saline nasal irrigation is an effective adjunctive treatment for symptoms of chronic rhinosinusitis. Larger prospective studies are needed in patients with these diagnoses.”

Georgitis JW. Nasal hyperthermia and simple irrigation for perennial rhinitis. Changes in inflammatory mediators. Chest, 106:1487–92, 1994

“Conclusions: This study demonstrated the usefulness of large particle vapor treatment and saline solution irrigation in reducing inflammatory mediators in nasal secretions and indirectly supports the clinical efficacy of these treatments for chronic rhinitis”.

Shoseyov D, et al. Treatment with hypertonic saline versus normal saline nasal wash of pediatric chronic sinusitis, J Allergy Clinical Immunol. 101(5): 602-605, 1998.
“The randomized double blind study showed that daily nasal wash with saline is an efficient treatment of chronic sinusitis.”\

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